Chrysanne Stathacos was born in Buffalo, New York. She studied fine arts at the Cleveland Institute of Art 1969-70, at York University, Toronto, Ontario, 1970-73, and at the Open Studio, Toronto, Ontario, 1975-76. She is known as an educator and a multi-media performance and interactive public projects artist. Some of her major works include 1-900, Mirror Mirror, a performance piece; The Wish Machine, her first interactive public art work; The Aura Project, Refuge, a Wish Garden, and The Roses. She has received awards from the Puffin Foundation in 2005, the Japan Foundation in 2001, the Adolph and Esther Gottlieb Foundation in 1998, and Art Matters in 1995. Her residence is found between Toronto and New York. She has participated in Green Machine, with composer Ben Neill; and One Night, One Garden One Wish with sound artist Andrew Zealley.
Her art has been shown in museums, public places and galleries all over the world, and is represented in many public collections, including the Albright-Knox Art Gallery, Buffalo, the Art Gallery of Greater Victoria, the Art Gallery of Hamilton, the Art Gallery of Ontario, Toronto, and the Memorial Art Gallery of the University of Rochester.