Leslie Bush was born in Toronto and pursued two distinct careers, in life-sciences and textile design. She studied both at the Ontario College of Art in Toronto, and Goldsmith College in London, England. Bush is the holder of several awards and scholarships from the Ontario College of Art and other institutions. Her passion for life-sciences and textiles aligned as Bush took part in two exhibits at the Central Hospital in Toronto, Ontario in 1983.
After working for many years at the University of Toronto, Leslie retired from the University in 2013, where she held the position of Assistant Vice-Provost, Health Sciences. Although Leslie does not work in the textile medium any more, she is a passionate photographer who expresses her creative side in photography.